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Intracellular VHHs to monitor and modulate GPCR signaling

Single-domain antibody fragments, also known as VHHs or nanobodies, have opened promising avenues in therapeutics and in exploration of intracellular processes. Because of their unique structural properties, they can reach cryptic regions in their cognate antigen. Intracellular VHHs/antibodies prima...

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Principais autores: Pauline Raynaud, Camille Gauthier, Vinesh Jugnarain, Frédéric Jean-Alphonse, Eric Reiter, Gilles Bruneau, Pascale Crépieux
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-11-01
Serier:Frontiers in Endocrinology
Fag:
G protein-coupled receptor
conformations
intracellular VHHs
Cell signaling
G proteins
β-arrestins
Online adgang:https://www.frontiersin.org/articles/10.3389/fendo.2022.1048601/full
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