Intracerebral Infusion of Antisense Oligonucleotides Into Prion-infected Mice
Mice deficient for the cellular prion protein (PrPC) do not develop prion disease; accordingly, gene-based strategies to diminish PrPC expression are of interest. We synthesized a series of chemically modified antisense oligonucleotides (ASOs) targeted against mouse Prnp messenger RNA (mRNA) and ide...
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| Principais autores: | , , , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Elsevier
2012-01-01
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| coleção: | Molecular Therapy: Nucleic Acids |
| Acesso em linha: | http://www.sciencedirect.com/science/article/pii/S2162253116300671 |
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