Pharmacokinetics of quinacrine in the treatment of prion disease
<p>Abstract</p> <p>Background</p> <p>Prion diseases are caused by the accumulation of an aberrantly folded isoform of the prion protein, designated PrP<sup>Sc</sup>. In a cell-based assay, quinacrine inhibits the conversion of normal host prion protein (PrP<sup>C</sup>) to PrP<sup>Sc </sup>at a half...
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| Principais autores: | , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
BMC
2004-11-01
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| coleção: | BMC Infectious Diseases |
| Acesso em linha: | http://www.biomedcentral.com/1471-2334/4/53 |
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