Loss of BCAA catabolism enhances Rab1A-mTORC1 signaling activity and promotes tumor proliferation in NSCLC

Background: Non-small cell lung cancer (NSCLC) is a leading cause of cancer death. Branched-chain amino acid (BCAA) homeostasis is important for normal physiological metabolism. Branched-chain keto acid dehydrogenase kinase (BCKDK) is a rate-limiting enzyme involved in BCAA degradation. BCAA metabol...

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主要な著者:	Meiting Xue, Jiawei Xiao, Wenna Jiang, Yanhui Wang, Duo Zuo, Haohua An, Li Ren
フォーマット:	Artigo
言語:	Inglês
出版事項:	Elsevier 2023-08-01
シリーズ:	Translational Oncology
主題:	BCAA catabolism BCKDK Rab1A mTORC1 NSCLC
オンライン･アクセス:	http://www.sciencedirect.com/science/article/pii/S1936523323000827
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