Characterization of a new specific mPGES-1 inhibitor in cardiovascular system

Abstract This study investigates the effects of BI 1,029,539 (GS-248 or Vipoglanstat), a novel selective inhibitor of human microsomal prostaglandin E synthase-1 (mPGES-1), in experimental models of myocardial infarction and vascular injury using transgenic mice constitutively expressing the humaniz...

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主要な著者:	Xinchun Lin, Huiying Feng, Jin-Rui Zhang, Malarvizhi Gurusamy, Saeed Nasseri, Anton Pekcec, Dongmei Wu
フォーマット:	Artigo
言語:	Inglês
出版事項:	Nature Portfolio 2025-12-01
シリーズ:	Scientific Reports
主題:	Myocardial infarction Vascular injury Vascular stenosis Smooth muscle cell proliferation MPGES-1 BI 1029539
オンライン･アクセス:	https://doi.org/10.1038/s41598-025-33453-1
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