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APOL1 Modulates Renin–Angiotensin System

Patients carrying APOL1 risk alleles (G1 and G2) have a higher risk of developing Focal Segmental Glomerulosclerosis (FSGS); we hypothesized that escalated levels of miR193a contribute to kidney injury by activating renin–angiotensin system (RAS) in the APOL1 milieus. Differentiated podocytes (DPDs)...

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Principais autores: Vinod Kumar, Prabhjot Kaur, Kameshwar Ayasolla, Alok Jha, Amen Wiqas, Himanshu Vashistha, Moin A. Saleem, Waldemar Popik, Ashwani Malhotra, Christoph A. Gebeshuber, Karl Skorecki, Pravin C. Singhal
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2024-12-01
Serier:Biomolecules
Fag:
APOL1
podocyte
renin-angiotensin system
miR193a
VDR
WT1
Online adgang:https://www.mdpi.com/2218-273X/14/12/1575
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