SREBP1c‐Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells

Abstract Acute kidney injury (AKI) is a prevalent clinical syndrome with high morbidity and mortality. Accumulating studies suggest mitochondrial dysfunction as the typical characteristics and key process of AKI, but the underlying mechanism remains elusive. The YME1‐like 1 (YME1L1) ATPase, an inner...

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Hlavní autoři:	Wang Xin, Jie Zhou, Yuzhu Peng, Shuiqin Gong, Wenhao Liao, Yaqin Wang, Xixin Huang, Yang Mao, Mengying Yao, Shaozong Qin, Jiachuan Xiong, Yan Li, Qigang Lan, Yinghui Huang, Jinghong Zhao
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Wiley 2025-02-01
Edice:	Advanced Science
Témata:	AKI Mitochondrial dysfunction SREBP1c YME1L1
On-line přístup:	https://doi.org/10.1002/advs.202412233
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