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SREBP1c‐Mediated Transcriptional Repression of YME1L1 Contributes to Acute Kidney Injury by Inducing Mitochondrial Dysfunction in Tubular Epithelial Cells

Abstract Acute kidney injury (AKI) is a prevalent clinical syndrome with high morbidity and mortality. Accumulating studies suggest mitochondrial dysfunction as the typical characteristics and key process of AKI, but the underlying mechanism remains elusive. The YME1‐like 1 (YME1L1) ATPase, an inner...

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Principais autores: Wang Xin, Jie Zhou, Yuzhu Peng, Shuiqin Gong, Wenhao Liao, Yaqin Wang, Xixin Huang, Yang Mao, Mengying Yao, Shaozong Qin, Jiachuan Xiong, Yan Li, Qigang Lan, Yinghui Huang, Jinghong Zhao
פורמט: Artigo
שפה:Inglês
יצא לאור: Wiley 2025-02-01
סדרה:Advanced Science
נושאים:
AKI
Mitochondrial dysfunction
SREBP1c
YME1L1
גישה מקוונת:https://doi.org/10.1002/advs.202412233
תגים: הוספת תג
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