Inherent fast inactivation particle of Nav channels as a new binding site for a neurotoxin

Abstract Neurotoxins derived from animal venoms are indispensable tools for probing the structure and function of voltage-gated sodium (Nav) channels. Utilizing a novel centipede peptide toxin called rpTx1, we show that the “inherent inactivation particle” of Nav channels represents a binding site f...

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Bibliografiska uppgifter

Huvudupphov:	Xi Zhou, Haiyi Chen, Shuijiao Peng, Yuxin Si, Gaoang Wang, Li Yang, Qing Zhou, Minjuan Lu, Qiaoling Xie, Xi He, Meijing Wu, Xin Xiao, Xiaoqing Luo, Xujun Feng, Wenxing Wang, Sen Luo, Yaqi Li, Jiaxin Qin, Minzhi Chen, Qianqian Zhang, Weijun Hu, Songping Liang, Tingjun Hou, Zhonghua Liu
Materialtyp:	Artigo
Språk:	Inglês
Utgiven:	Springer Nature 2025-04-01
Serie:	The EMBO Journal
Ämnen:	Sodium Channels Peptide Toxins Fast Inactivation Gate Neurotoxins Binding Sites Intracellular Modulation
Länkar:	https://doi.org/10.1038/s44318-025-00438-9
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