Intracellular delivery of protein drugs with an autonomously lysing bacterial system reduces tumor growth and metastases

The limited ability of cancer therapeutics in crossing the cancer cell membrane hampers their therapeutic potential. Here, the authors report Salmonella-based system for intracellular delivery of protein drugs, e.g. caspase-3, and show reduction of tumors in mouse models of breast and liver cancer.

Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Vishnu Raman, Nele Van Dessel, Christopher L. Hall, Victoria E. Wetherby, Samantha A. Whitney, Emily L. Kolewe, Shoshana M. K. Bloom, Abhinav Sharma, Jeanne A. Hardy, Mathieu Bollen, Aleyde Van Eynde, Neil S. Forbes
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Nature Portfolio 2021-10-01
Rangatū:	Nature Communications
Urunga tuihono:	https://doi.org/10.1038/s41467-021-26367-9
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!