Intracellular Hyper-Acidification Potentiated by Hydrogen Sulfide Mediates Invasive and Therapy Resistant Cancer Cell Death

Slow and continuous release of H2S by GYY4137 has previously been demonstrated to kill cancer cells by increasing glycolysis and impairing anion exchanger and sodium/proton exchanger activity. This action is specific for cancer cells. The resulting lactate overproduction and defective pH homeostasis...

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Ngā taipitopito rārangi puna kōrero

Ngā kaituhi matua:	Zheng-Wei Lee, Xin-Yi Teo, Zhi J. Song, Dawn S. Nin, Wisna Novera, Bok A. Choo, Brian W. Dymock, Philip K. Moore, Ruby Y.-J. Huang, Lih-Wen Deng
Hōputu:	Artigo
Reo:	Inglês
I whakaputaina:	Frontiers Media S.A. 2017-10-01
Rangatū:	Frontiers in Pharmacology
Ngā marau:	hydrogen sulfide invasive cancer lactate therapy resistance intracellular acidification
Urunga tuihono:	http://journal.frontiersin.org/article/10.3389/fphar.2017.00763/full
Ngā Tūtohu:	Tāpirihia he Tūtohu Kāore He Tūtohu, Me noho koe te mea tuatahi ki te tūtohu i tēnei pūkete!