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Albumin Protects Against Cyclophosphamide-Induced Hemorrhagic Cystitis by Scavenging Acrolein and Reactive Oxygen Species

Cyclophosphamide (CYP) is an effective chemotherapeutic, but its use is limited by hemorrhagic cystitis caused by its toxic metabolite acrolein. Acrolein, when concentrated in the urine, triggers oxidative stress, leading to urothelial inflammation and cell death. Given that albumin is the most abun...

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Hoofdauteurs: Zhuheng Shi, Zhimin Mao, Yingyu Zhang, Xiaoyu Su, Rui Jiang, Yang Sui, Xin Wang, Jie Cheng, Manabu Niimi, Jianglin Fan, Jian Yao
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: MDPI AG 2026-04-01
Reeks:Biomolecules
Onderwerpen:
albumin
cyclophosphamide
acrolein
ferroptosis
cystitis
oxidative stress
Online toegang:https://www.mdpi.com/2218-273X/16/4/536
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