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Albumin Protects Against Cyclophosphamide-Induced Hemorrhagic Cystitis by Scavenging Acrolein and Reactive Oxygen Species

Cyclophosphamide (CYP) is an effective chemotherapeutic, but its use is limited by hemorrhagic cystitis caused by its toxic metabolite acrolein. Acrolein, when concentrated in the urine, triggers oxidative stress, leading to urothelial inflammation and cell death. Given that albumin is the most abun...

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Principais autores: Zhuheng Shi, Zhimin Mao, Yingyu Zhang, Xiaoyu Su, Rui Jiang, Yang Sui, Xin Wang, Jie Cheng, Manabu Niimi, Jianglin Fan, Jian Yao
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2026-04-01
Serier:Biomolecules
Fag:
albumin
cyclophosphamide
acrolein
ferroptosis
cystitis
oxidative stress
Online adgang:https://www.mdpi.com/2218-273X/16/4/536
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