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Increased levels and activation of the IL-17 receptor in microglia contribute to enhanced neuroinflammation in cerebellum of hyperammonemic rats

Abstract Background Patients with liver cirrhosis may show minimal hepatic encephalopathy (MHE) with mild cognitive impairment and motor incoordination. Rats with chronic hyperammonemia reproduce these alterations. Motor incoordination in hyperammonemic rats is due to increased GABAergic neurotransm...

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Principais autores: Yaiza M. Arenas, Adrià López-Gramaje, Carmina Montoliu, Marta Llansola, Vicente Felipo
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2024-04-01
Serier:Biological Research
Fag:
Cerebellum
Hyperammonemia
IL-17
Neuroinflammation
Microglia
Hepatic encephalopathy
Online adgang:https://doi.org/10.1186/s40659-024-00504-2
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