DRP1 downregulation impairs mitophagy, driving mitochondrial ROS and SASP production in rheumatoid arthritis CD4+PD-1+T cells

T cell senescence occurs in patients with rheumatoid arthritis (RA), but the specific phenotype and its contribution to tissue-destructive inflammation remain unclear. Here, we aim to investigate whether PD-1 marks pathogenic senescent CD4+T cells and to explore the role and mechanism of senescent C...

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Autores principales:	Ziran Bai, Jinyi Ren, Jiaqing Liu, Cheng Zhang, Huina Huang, Xiangge Zhao, Xianmei Chen, Jing Wei, Jingjing Qi, Siwen Yang, Weiping Li, Yawei Tang, Guan Wang, Xia Li
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	Elsevier 2025-10-01
Colección:	Redox Biology
Materias:	Rheumatoid arthritis CD4+PD-1+T cells Senescence-associated secretory phenotype Dynamin-related protein 1 Mitochondrial reactive oxygen species
Acceso en línea:	http://www.sciencedirect.com/science/article/pii/S2213231725003313
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