Inhibition of Acid Sphingomyelinase by Antidepressants Counteracts Stress-Induced Activation of P38-Kinase in Major Depression

Background/Aims: Major depressive disorder is a common disease with serious morbidity, including increased risk of death from suicide. Major depressive disorder is treated with antidepressants. However, the molecular targets of antidepressants remained ill-defined and require further elucidation. Me...

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Detalhes bibliográficos

Principais autores:	Heike Grassmé, Peter L. Jernigan, Richard S. Hoehn, Barbara Wilker, Matthias Soddemann, Michael J. Edwards, Christian P. Müller, Johannes Kornhuber, Erich Gulbins
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Cell Physiol Biochem Press GmbH & Co KG 2015-12-01
coleção:	Neurosignals
Assuntos:	p38 Kinase Neurogenesis Ceramide Acid sphingomyelinase Antidepressants
Acesso em linha:	http://www.karger.com/Article/FullText/442606
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