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Regulation of hematogenous tumor metastasis by acid sphingomyelinase

Abstract Metastatic dissemination of cancer cells is the ultimate hallmark of malignancy and accounts for approximately 90% of human cancer deaths. We investigated the role of acid sphingomyelinase (Asm) in the hematogenous metastasis of melanoma cells. Intravenous injection of B16F10 melanoma cells...

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Auteurs principaux: Alexander Carpinteiro, Katrin Anne Becker, Lukasz Japtok, Gabriele Hessler, Simone Keitsch, Miroslava Požgajovà, Kurt W Schmid, Constantin Adams, Stefan Müller, Burkhard Kleuser, Michael J Edwards, Heike Grassmé, Iris Helfrich, Erich Gulbins
Format: Artigo
Langue:Inglês
Publié: Springer Nature 2015-04-01
Collection:EMBO Molecular Medicine
Sujets:
acid sphingomyelinase
ceramide
integrins
platelets
tumor‐metastasis
Accès en ligne:https://doi.org/10.15252/emmm.201404571
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