From the Pain Matrix to Functional Networks: A Narrative Review of Chronic Pain Mechanisms Across Adult and Pediatric Populations with Emerging AI Perspectives

<b>Background:</b> While region-based models have informed pain neuroscience, chronic pain is now increasingly conceptualized as a network disorder. This narrative review aimed to critically examine the conceptual evolution of chronic pain models from region-based representations toward large-scale...

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Detalhes bibliográficos

Principais autores:	Marco Cascella, Daniela Siano, Mauro D’Amora, Corrado Cecchetti, Alessandro Vittori, Maria Romano, Vittorio Santoriello
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2026-06-01
Colecção:	Brain Sciences
Assuntos:	chronic pain pediatric pain pain chronification neuroplasticity functional connectivity brain networks
Acesso em linha:	https://www.mdpi.com/2076-3425/16/6/639
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