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From the Pain Matrix to Functional Networks: A Narrative Review of Chronic Pain Mechanisms Across Adult and Pediatric Populations with Emerging AI Perspectives

<b>Background:</b> While region-based models have informed pain neuroscience, chronic pain is now increasingly conceptualized as a network disorder. This narrative review aimed to critically examine the conceptual evolution of chronic pain models from region-based representations toward large-scale...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Marco Cascella, Daniela Siano, Mauro D’Amora, Corrado Cecchetti, Alessandro Vittori, Maria Romano, Vittorio Santoriello
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI AG 2026-06-01
Schriftenreihe:Brain Sciences
Schlagworte:
chronic pain
pediatric pain
pain chronification
neuroplasticity
functional connectivity
brain networks
Online-Zugang:https://www.mdpi.com/2076-3425/16/6/639
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