Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

Oxidative stress is a hallmark of Alzheimer’s disease (AD). We propose that rather than causing damage because of the action of free radicals, oxidative stress deranges signaling pathways leading to tau hyperphosphorylation, a hallmark of the disease. Indeed, incubation of neurons in culture with 5 ...

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Bibliografische Detailangaben

Hauptverfasser:	E. Giraldo, A. Lloret, T. Fuchsberger, J. Viña
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Elsevier 2014-01-01
Schriftenreihe:	Redox Biology
Schlagworte:	Vitamin E Antioxidant Beta-amyloid P-p38
Online-Zugang:	http://www.sciencedirect.com/science/article/pii/S2213231714000494
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