Aβ and tau toxicities in Alzheimer’s are linked via oxidative stress-induced p38 activation: Protective role of vitamin E

Oxidative stress is a hallmark of Alzheimer’s disease (AD). We propose that rather than causing damage because of the action of free radicals, oxidative stress deranges signaling pathways leading to tau hyperphosphorylation, a hallmark of the disease. Indeed, incubation of neurons in culture with 5 ...

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Prif Awduron:	E. Giraldo, A. Lloret, T. Fuchsberger, J. Viña
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Elsevier 2014-01-01
Cyfres:	Redox Biology
Pynciau:	Vitamin E Antioxidant Beta-amyloid P-p38
Mynediad Ar-lein:	http://www.sciencedirect.com/science/article/pii/S2213231714000494
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!