MiR-451a and let-7i-5p loaded extracellular vesicles attenuate heme-induced inflammation in hiPSC-derived endothelial cells

Hemolysis is associated with many pathologies, including trauma, sepsis, hemorrhagic stroke, malaria, and genetic disorders such as sickle cell disease (SCD). When hemolysis occurs, free-heme drives vascular inflammation, resulting in oxidative tissue damage and cardiometabolic complications. A bett...

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Principais autores:	Justin J. Thomas, Keri Oxendine Harp, Alaijah Bashi, Joshua L. Hood, Felix Botchway, Michael D. Wilson, Winston E. Thompson, Jonathan K. Stiles, Adel Driss
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2022-12-01
coleção:	Frontiers in Immunology
Assuntos:	malaria sickle cell anemia extracellular vesicles micro-RNA hiPSC inflammation
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2022.1082414/full
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