α-(Aminomethyl)acrylates as acceptors in radical–polar crossover 1,4-additions of dialkylzincs: insights into enolate formation and trapping

We demonstrate that α-(aminomethyl)acrylates are suitable acceptors for 1,4-additions of dialkylzincs in aerobic conditions. The air-promoted radical–polar crossover process involves the 1,4-addition of an alkyl radical followed by homolytic substitution at the zinc atom of dialkylzinc. Coordination...

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Detalles Bibliográficos

Principais autores:	Angel Palillero-Cisneros, Paola G. Gordillo-Guerra, Fernando García-Alvarez, Olivier Jackowski, Franck Ferreira, Fabrice Chemla, Joel L. Terán, Alejandro Perez-Luna
Formato:	Artigo
Idioma:	Inglês
Publicado:	Beilstein-Institut 2023-09-01
Series:	Beilstein Journal of Organic Chemistry
Assuntos:	β-amino acids tandem reactions radical–polar crossover tert-butanesulfinamide zinc radical transfer
Acceso en liña:	https://doi.org/10.3762/bjoc.19.103
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