Invasive brain mapping identifies personalized therapeutic neuromodulation targets that suppress OCD network activity

Abstract Deep brain stimulation has been used to treat severe, refractory obsessive-compulsive disorder (OCD) with variable outcomes across multiple anatomical targets. To overcome these limitations, we developed an invasive brain mapping paradigm in which electrodes were implanted across the OCD co...

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Detalles Bibliográficos

Principais autores:	A. Moses Lee, Audrey Kist, John Alvarez, Kristin K. Sellers, Ankit N. Khambhati, Leo P. Sugrue, Lee B. Reid, Kelly Kadlec, Sneha Ray, Joline M. Fan, Anusha B. Allawala, Caroline A. Racine, Tenzin Norbu, Dani Astudillo, Alexandra G. Tremblay-McGaw, Natalie Becker, Jessica Verhein, Ahmad Alhourani, Philip A. Starr, Edward F. Chang, Andrew D. Krystal
Formato:	Artigo
Idioma:	Inglês
Publicado:	Nature Publishing Group 2025-10-01
Series:	Translational Psychiatry
Acceso en liña:	https://doi.org/10.1038/s41398-025-03690-z
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