Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

ABSTRACT To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quality compared with the founder Sprague–Dawley (SD) rat...

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Hlavní autoři:	Nancy S Krieger, Luojing Chen, Jennifer Becker, Sean DeBoyace, Hongwei Wang, Murray J Favus, David A Bushinsky
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Oxford University Press 2020-04-01
Edice:	JBMR Plus
Témata:	GENETIC ANIMAL MODELS OSTEOBLASTS OSTEOCLASTS STROMAL/STEM CELLS DISORDERS OF CALCIUM AND PHOSPHATE METABOLISM
On-line přístup:	https://doi.org/10.1002/jbm4.10350
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