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Increased Osteoclast and Decreased Osteoblast Activity Causes Reduced Bone Mineral Density and Quality in Genetic Hypercalciuric Stone‐Forming Rats

ABSTRACT To study human idiopathic hypercalciuria (IH), we developed an animal model, genetic hypercalciuric stone‐forming (GHS) rats, whose pathophysiology parallels that in IH. All GHS rats form kidney stones and have decreased BMD and bone quality compared with the founder Sprague–Dawley (SD) rat...

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Principais autores: Nancy S Krieger, Luojing Chen, Jennifer Becker, Sean DeBoyace, Hongwei Wang, Murray J Favus, David A Bushinsky
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2020-04-01
coleção:JBMR Plus
Assuntos:
GENETIC ANIMAL MODELS
OSTEOBLASTS
OSTEOCLASTS
STROMAL/STEM CELLS
DISORDERS OF CALCIUM AND PHOSPHATE METABOLISM
Acesso em linha:https://doi.org/10.1002/jbm4.10350
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