Synthesis, Antibacterial Properties and Molecular Docking Studies of Nitrogen Substituted 9-(((4X-But-2-ynyloxy)methyl)-1,2,3-triazolyl)–Cinchona Alkaloid Conjugates

The year 2024 marked the 80th anniversary of Woodward’s total synthesis of quinine. Quinine is a natural alkaloid from the bark of the cinchona tree that has been used for years as an antimalarial drug. The antibacterial effect of quinine salts has also been regarded. With this in mind, a series of...

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Hauptverfasser:	Gulim K. Mukusheva, Nurizat N. Toigambekova, Victor A. Savelyev, Andrey I. Khlebnikov, Liubov G. Burova, Sofiia D. Afanaseva, Oralgazy A. Nurkenov, Anarkul S. Kishkentayeva, Aikerim S. Olzhabayeva, Yurii V. Gatilov, Roza B. Seidakhmetova, Alexander N. Evstropov, Elvira E. Shults
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2025-11-01
Schriftenreihe:	Molecules
Schlagworte:	cinchona alkaloids quinine triazoles A<sup>3</sup>-coupling reactions antibacterial activity bacterial biofilms
Online-Zugang:	https://www.mdpi.com/1420-3049/30/22/4352
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