Topological determinants in protein folding dynamics: a comparative analysis of metamorphic proteins

Abstract Protein folding remains a fundamental challenge in molecular biology, particularly in understanding how polypeptide chains transition from denatured states to their functional conformations. Here we analyze the folding mechanisms of the engineered metamorphic proteins B4 and Sb3, which shar...

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Hlavní autoři:	Julian Toso, Valeria Pennacchietti, Mariana Di Felice, Eduarda S. Ventura, Angelo Toto, Stefano Gianni
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-04-01
Edice:	Biology Direct
Témata:	Protein folding Kinetics Metamorphic proteins Site-directed mutagenesis
On-line přístup:	https://doi.org/10.1186/s13062-025-00642-x
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