NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression
Abstract Background Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation. NSUN2, a 5-methylcytosine (m5C) methyltransferase of tRNA, is elevated in an array of solid cancers, including triple-negative bre...
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| Autores principales: | , , , , , |
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| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
BMC
2025-08-01
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| Colección: | Cellular & Molecular Biology Letters |
| Materias: | |
| Acceso en línea: | https://doi.org/10.1186/s11658-025-00781-z |
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