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NSUN2–tRNAVal−CAC-axis-regulated codon-biased translation drives triple-negative breast cancer glycolysis and progression

Abstract Background Epitranscriptomic data indicate that aberrant tRNA modifications in malignant diseases can promote tumor growth by facilitating oncogene translation. NSUN2, a 5-methylcytosine (m5C) methyltransferase of tRNA, is elevated in an array of solid cancers, including triple-negative bre...

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Principais autores: Wenlong Wang, Ying Ding, Haixi Zhao, Shouman Wang, Juan Huang, Lunquan Sun
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2025-08-01
Serier:Cellular & Molecular Biology Letters
Fag:
NSUN2
tRNA
m5C modification
Metabolism reprogramming
Triple-negative breast cancer
Online adgang:https://doi.org/10.1186/s11658-025-00781-z
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