Isoform-specific vs. pan-histone deacetylase inhibition as approaches for countering glioblastoma: an in vitro study

IntroductionGlioblastoma (GBM) is a grade 4 brain tumor that originates in astrocytes. GBM has a high death rate and a very low median patient survival rate of 14–16 months, even with well-established treatment regimens. The majority of preclinical models assess the effectiveness of molecular leads...

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Hauptverfasser:	Ameya Joshi, Natasha Ratnapradipa, Jayce Hughes, Erik Moore, Andrew Ekpenyong, Surabhi Shukla
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Frontiers Media S.A. 2025-11-01
Schriftenreihe:	Frontiers in Oncology
Schlagworte:	glioblastoma HDAC inhibitors Vorinostat Trichostatin-A Tubacin temozolomide
Online-Zugang:	https://www.frontiersin.org/articles/10.3389/fonc.2025.1695552/full
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