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Isoform-specific vs. pan-histone deacetylase inhibition as approaches for countering glioblastoma: an in vitro study

IntroductionGlioblastoma (GBM) is a grade 4 brain tumor that originates in astrocytes. GBM has a high death rate and a very low median patient survival rate of 14–16 months, even with well-established treatment regimens. The majority of preclinical models assess the effectiveness of molecular leads...

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Principais autores: Ameya Joshi, Natasha Ratnapradipa, Jayce Hughes, Erik Moore, Andrew Ekpenyong, Surabhi Shukla
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-11-01
Serier:Frontiers in Oncology
Fag:
glioblastoma
HDAC inhibitors
Vorinostat
Trichostatin-A
Tubacin
temozolomide
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1695552/full
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