Hiding in plain sight: structure and sequence analysis reveals the importance of the antibody DE loop for antibody-antigen binding

Antibody variable domains contain “complementarity-determining regions” (CDRs), the loops that form the antigen binding site. CDRs1-3 are recognized as the canonical CDRs. However, a fourth loop sits adjacent to CDR1 and CDR2 and joins the D and E strands on the antibody v-type fold. This “DE loop”...

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Bibliografische Detailangaben

Hauptverfasser:	Simon P. Kelow, Jared Adolf-Bryfogle, Roland L. Dunbrack
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	Taylor & Francis Group 2020-01-01
Schriftenreihe:	mAbs
Schlagworte:	Antibody therapeutics antibody structure structural bioinformatics antibody complementarity determining regions
Online-Zugang:	https://www.tandfonline.com/doi/10.1080/19420862.2020.1840005
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