Clinically Relevant Plasmid-Host Interactions Indicate that Transcriptional and Not Genomic Modifications Ameliorate Fitness Costs of <italic toggle="yes">Klebsiella pneumoniae</italic> Carbapenemase-Carrying Plasmids

ABSTRACT The rapid dissemination of antimicrobial resistance (AMR) around the globe is largely due to mobile genetic elements, such as plasmids. They confer resistance to critically important drugs, including extended-spectrum beta-lactams, carbapenems, and colistin. Large, complex resistance plasmi...

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Autori principali:	Michelle M. C. Buckner, Howard T. H. Saw, Rachael N. Osagie, Alan McNally, Vito Ricci, Matthew E. Wand, Neil Woodford, Alasdair Ivens, Mark A. Webber, Laura J. V. Piddock
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology 2018-05-01
Serie:	mBio
Soggetti:	fitness Klebsiella pneumoniae carbapenemase (KPC) genome pKpQIL plasmid transcriptome
Accesso online:	https://journals.asm.org/doi/10.1128/mBio.02303-17
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