Germ Cell Maintenance and Sustained Testosterone and Precursor Hormone Production in Human Prepubertal Testis Organ Culture with Tissues from Boys 7 Years+ under Conditions from Adult Testicular Tissue

Human prepubertal testicular tissues are rare, but organ culture conditions to develop a system for human in vitro-spermatogenesis are an essential option for fertility preservation in prepubertal boys subjected to gonadotoxic therapy. To avoid animal testing in line with the 3Rs principle, organ cu...

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Detalhes bibliográficos

Principais autores:	Neels Lennart Aden, Matthias Bleeke, Uwe R. Kordes, Bianka Brunne, Barbara Holstermann, Ronald Biemann, Uta Ceglarek, Armin Soave, Andrea Salzbrunn, Stefan W. Schneider, Kathrein von Kopylow
Formato:	Artigo
Idioma:	Inglês
Publicado em:	MDPI AG 2023-01-01
coleção:	Cells
Assuntos:	prepubertal boys fertility preservation testis organ culture in vitro culture spermatogonia spermatogonial stem cells
Acesso em linha:	https://www.mdpi.com/2073-4409/12/3/415
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