Decreased expression of GGA3 Protein in Alzheimer's disease frontal cortex and increased co-distribution of BACE with the amyloid precursor protein

BACE initiates the amyloidogenic processing of the amyloid precursor protein (APP) that results in the production of Aβ peptides associated with Alzheimer's disease (AD). Previous studies have indicated that BACE is elevated in the frontal cortex of AD patients. Golgi-localized γ-ear containing ADP...

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Detalhes bibliográficos

Principais autores:	Claudia Santosa, Stefanie Rasche, Adel Barakat, Shayne A. Bellingham, Michael Ho, Jiangli Tan, Andrew F. Hill, Colin L. Masters, Catriona McLean, Geneviève Evin
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2011-07-01
coleção:	Neurobiology of Disease
Assuntos:	BACE1 Secretase Amyloid precursor protein Alzheimer's disease
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S096999611100091X
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