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Synaptic dysfunction and glial activation markers throughout aging and early neurodegeneration: a longitudinal CSF biomarker-based study

Abstract Background Synaptic homeostasis, maintained by microglia and astroglia, is disrupted throughout aging and early on in neurodegenerative diseases. Our aim was to study the relationship between TREM2-dependent microglial reactivity, astroglial response and synaptic dysfunction in two longitud...

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Principais autores: Mariana I. Muñoz-García, Yuetiva Deming, Ferran Lugo-Hernández, Sterling Johnson, Sanjay Asthana, Gwendlyn Kollmorgen, Clara Quijano-Rubio, Cynthia Carlsson, Ozioma C. Okonkwo, David Pérez-Martinez, Alberto Villarejo-Galende, Kaj Blennow, Marc Suárez-Calvet, Henrik Zetterberg, Barbara B. Bendlin, Estrella Morenas-Rodríguez
Formato: Artigo
Idioma:Inglês
Publicado em: BMC 2025-10-01
coleção:Molecular Neurodegeneration
Assuntos:
Microglia
Synaptic function
Aging
Neurodegeneration
TREM2
Acesso em linha:https://doi.org/10.1186/s13024-025-00901-5
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