Restoring colistin sensitivity in colistin-resistant gram-negative bacteria: combinatorial use of α-terpineol and colistin

ABSTRACT Multidrug-resistant gram-negative bacteria (GNB) have posed a serious public health hazard worldwide. Colistin (COL), the ultimate therapeutic option for treating GNB infections, has had escalating resistance rates concomitant with increased utilization. In this study, we attempted to incre...

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Main Authors: Yuhan Yang, Panjie Hu, Yanchun Gong, Zeyong Zhong, Yichi Zhang, Fan Ye, Tieli Zhou, Jianming Cao, Zhongyong Wang
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2025-11-01
Series:Microbiology Spectrum
Assuntos:
gram-negative bacteria
colistin resistance
α-terpineol
synergistic antimicrobial effects
biofilm
Acceso en liña:https://journals.asm.org/doi/10.1128/spectrum.00825-25
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