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The synergistic antibacterial effects of α-mangostin and colistin on colistin-resistant Gram-negative bacteria

Objective: Colistin (COL) remains a critical therapeutic agent for multidrug-resistant Gram-negative bacterial infections caused by pathogens. However, its clinical utility is increasingly constrained by escalating resistance rates and significant nephrotoxicity/neurotoxicity. In this study, we inno...

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Principais autores: Fan Ye, Xiaowei Lv, Wenhui Guo, Panjie Hu, Mengjie Wei, Yuhan Yang, Tieli Zhou, Qing Wu
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-12-01
Serier:Journal of Global Antimicrobial Resistance
Fag:
Gram-negative bacteria
Colistin resistance
α-Mangostin
Synergistic
Biofilm
Online adgang:http://www.sciencedirect.com/science/article/pii/S221371652500236X
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