Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional

Abstract Background Although the Cox time-varying coefficient (TVC) model has been developed to address non-proportional hazard (PH), its use remains underexplored. Instead, the restricted mean survival time (RMST) has been widely used in non-PH settings to quantify treatment effects using life expe...

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Autors principals:	Tianyuan Gu, Zhaojin Chen, Yu Yang Soon, Joseph Wee, Bee-Choo Tai
Format:	Artigo
Idioma:	Inglês
Publicat:	BMC 2025-07-01
Col·lecció:	BMC Medical Research Methodology
Matèries:	Restricted mean survival time, Time Varying coefficient Cox model, Non Proportional hazards, Flexible parametric model, Time To Event outcomes
Accés en línia:	https://doi.org/10.1186/s12874-025-02608-z
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