Restricted mean survival time approach versus time-varying coefficient Cox model for quantifying treatment effect when hazards are non-proportional

Abstract Background Although the Cox time-varying coefficient (TVC) model has been developed to address non-proportional hazard (PH), its use remains underexplored. Instead, the restricted mean survival time (RMST) has been widely used in non-PH settings to quantify treatment effects using life expe...

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Hlavní autoři:	Tianyuan Gu, Zhaojin Chen, Yu Yang Soon, Joseph Wee, Bee-Choo Tai
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2025-07-01
Edice:	BMC Medical Research Methodology
Témata:	Restricted mean survival time, Time Varying coefficient Cox model, Non Proportional hazards, Flexible parametric model, Time To Event outcomes
On-line přístup:	https://doi.org/10.1186/s12874-025-02608-z
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