κB-Ras and Ral GTPases regulate acinar to ductal metaplasia during pancreatic adenocarcinoma development and pancreatitis

The molecular mechanisms of acinar-to-ductal metaplasia (ADM) in the course of pancreatitis and cancer development are unclear. Here, the authors show that loss of κB-Ras and consequent Ral activation promotes tumour initiation and progression through persistent ADM and enhanced cell proliferation

Detalhes bibliográficos

Principais autores:	Stephanie Beel, Lina Kolloch, Lisa H. Apken, Lara Jürgens, Andrea Bolle, Nadine Sudhof, Sankar Ghosh, Eva Wardelmann, Michael Meisterernst, Konrad Steinestel, Andrea Oeckinghaus
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2020-07-01
coleção:	Nature Communications
Acesso em linha:	https://doi.org/10.1038/s41467-020-17226-0
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