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Metformin Alleviates Radiation-Induced Skin Fibrosis via the Downregulation of FOXO3

Background/Aims: Radiation-induced skin fibrosis is a common side effect of clinical radiotherapy. Our previous next-generation sequencing (NGS) study demonstrated the reduced expression of the regulatory α subunit of phosphatidylinositol 3-kinase (PIK3r1) in irradiated murine skin. Metformin has be...

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Principais autores: Jin-Mo Kim, Hyun Yoo, Jee-Youn Kim, Sang Ho Oh, Jeong Wook Kang, Byung Rok Yoo, Song Yee Han, Cha Soon Kim, Won Hoon Choi, Eun-Jung Lee, Hyeong Ju Byeon, Won Jai Lee, Yun-Sil Lee, Jaeho  Cho
Formato: Artigo
Idioma:Inglês
Publicado em: Cell Physiol Biochem Press GmbH & Co KG 2018-07-01
coleção:Cellular Physiology and Biochemistry
Assuntos:
Radiation-induced skin fibrosis
Metformin
FOXO3
PIK3r1
Acesso em linha:https://www.karger.com/Article/FullText/491964
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