Epigenetic inhibition of class I histone deacetylases by MS-275 attenuates diabetic skeletal muscle atrophy via Akt/ARK5–FoxO and myostatin–Smad signaling

BackgroundSarcopenia is highly prevalent in individuals with diabetes and is associated with impaired physical function and increased mortality. Diabetes-associated skeletal muscle atrophy is driven by chronic inflammation, dysregulated anabolic–catabolic signaling, and activation of ubiquitin–prote...

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Bibliografiske detaljer

Principais autores:	Youngho Son, Hye-Eun Byeon, Sung-E Choi, Youngha Kim, Yu Jung Heo, Soon Beom Kwon, Jaemyung Choi, Seung Jin Han, Jayoung Jeon, Hae Jin Kim, Nami Lee, Kwan-Woo Lee
Format:	Artigo
Sprog:	Inglês
Udgivet:	Frontiers Media S.A. 2026-03-01
Serier:	Frontiers in Endocrinology
Fag:	AKT/FoxO signaling db/db mouse diabetic sarcopenia epigenetic regulation histone deacetylase myostatin
Online adgang:	https://www.frontiersin.org/articles/10.3389/fendo.2026.1788603/full
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