COPI mediates recycling of an exocytic SNARE by recognition of a ubiquitin sorting signal

The COPI coat forms transport vesicles from the Golgi complex and plays a poorly defined role in endocytic trafficking. Here we show that COPI binds K63-linked polyubiquitin and this interaction is crucial for trafficking of a ubiquitinated yeast SNARE (Snc1). Snc1 is a v-SNARE that drives fusion of...

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Detalhes bibliográficos

Principais autores:	Peng Xu, Hannah M Hankins, Chris MacDonald, Samuel J Erlinger, Meredith N Frazier, Nicholas S Diab, Robert C Piper, Lauren P Jackson, Jason A MacGurn, Todd R Graham
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2017-10-01
coleção:	eLife
Assuntos:	membrane trafficking COPI ubiquitin SNARE recycling
Acesso em linha:	https://elifesciences.org/articles/28342
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