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Macrophage-specific PHGDH protects against MAFLD by suppressing TAK1

Summary: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a progressive disease with only one approved treatment currently available. Hepatic phosphoglycerate dehydrogenase (PHGDH), the rate-limiting enzyme of the serine biosynthesis pathway, regulates MAFLD development. However, the...

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Principais autores: Penghui Hu, Xiao Shan, Hongyuan Dong, Sujun Yu, Baochen Wang, Hui Xiong, Zemin Ji, Weijia Jing, Yan Cui, Zihan Li, Yanzhao Zhou, Zhe Wang, Jinrong Wang, Jiuzhou Tang, Ting Wang, Keliang Xie, Qiujing Yu
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2025-03-01
coleção:Cell Reports
Assuntos:
CP: Metabolism
CP: Immunology
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2211124725001974
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