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A fully human IgG1 antibody targeting MICA α1 domain inhibits interaction with NKG2D and activates immune effector functions against MICA-expressing cells

BackgroundMICA is a stress-induced ligand for the activating receptor NKG2D and plays a central role in immune recognition and elimination of tumor cells. Tumor-derived soluble MICA (sMICA) and its allelic diversity impair immune responses by disrupting NKG2D function and promoting immune evasion, h...

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Principais autores: Ivo Campos, Fabiola González-Herrera, Yuneisy Guerra, María José Garrido, Nicolás Fehring, Carla Diaz, Douglas J. Matthies, Mauricio González, Samantha Tello, Fabián Tempio, Gonzalo Vásquez, Jose Rodríguez-Siza, Matías Gutiérrez, Lorenzo Leiva, Alfonso Romero, Norberto Collazo, Roberto Zúñiga, Carolina Valck, Carolina H. Ribeiro, Claudia Altamirano, Karen Toledo-Stuardo, María Carmen Molina
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2026-02-01
coleção:Frontiers in Immunology
Assuntos:
ADCC
ADCP
cancer immunotherapy
CDC
full human antibody
MICA
Acesso em linha:https://www.frontiersin.org/articles/10.3389/fimmu.2026.1740184/full
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