A paradigm shift in simulating affinity maturation to elicit broadly neutralizing antibodies

Broadly neutralizing antibodies (bnAbs) offer a promising route to protect against rapidly evolving pathogens such as HIV, influenza, and SARS-CoV-2, yet eliciting them through vaccination remains a significant challenge. A key to this problem lies in understanding antibody affinity maturation (AM),...

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Main Authors: Fahsai Nakarin, Kayla G. Sprenger
Formato: Artigo
Idioma:Inglês
Publicado: Frontiers Media S.A. 2025-07-01
Series:Frontiers in Immunology
Assuntos:
affinity maturation
germinal center
simulation
broadly neutralizing antibody
B cell
Acceso en liña:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1627674/full
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