Role of framework mutations and antibody flexibility in the evolution of broadly neutralizing antibodies

Eliciting antibodies that are cross reactive with surface proteins of diverse strains of highly mutable pathogens (e.g., HIV, influenza) could be key for developing effective universal vaccines. Mutations in the framework regions of such broadly neutralizing antibodies (bnAbs) have been reported to...

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Xehetasun bibliografikoak

Egile Nagusiak:	Victor Ovchinnikov, Joy E Louveau, John P Barton, Martin Karplus, Arup K Chakraborty
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	eLife Sciences Publications Ltd 2018-02-01
Saila:	eLife
Gaiak:	affinity maturation broadly neutralizing antibodies molecular dynamics framework mutations HIV
Sarrera elektronikoa:	https://elifesciences.org/articles/33038
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