The molecular basis of JAK/STAT inhibition by SOCS1
Cytokines are key molecules in controlling haematopoiesis that signal via the JAK/STAT pathway. Here the authors present the structures of SOCS1 bound to its JAK1 target as well as in complex with elonginB and elonginC, providing a molecular explanation for the potent JAK- inhibitory activity of SOC...
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| Principais autores: | , , , , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Portfolio
2018-04-01
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| coleção: | Nature Communications |
| Acesso em linha: | https://doi.org/10.1038/s41467-018-04013-1 |
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